EHI Peer-Reviewed Journal Publications

EHI Peer-Reviewed Journal Publications (Year 2010-2013)


  1. Lee, R.C., Hapuarachchi, H.C., Chen, K.C., Hussain, K.M., Chen, H., Low, S.L., Ng, L.C., Lin, R., Ng, M.M., Chu, J.J. (2013). Mosquito cellular factors and functions in mediating the infectious entry of chikungunya virus. PLoS Neglected Tropical Diseases;7(2): e2050. [Full Text]
  2. Hapuarachchi, H.C., Oh, H.M., Thein, T.L., Pok, K.Y., Lai, Y.L., Tan, L.K., Lee, K.S., Leo, Y.S., Ng, L.C. (2013). Clinico-genetic characterisation of an encephalitic dengue virus 4 associated with multi-organ involvement. Journal of Clinical Virology; 57(1): 91-94. [Full Text]
  3. Lee, C., Vythilingam, I., Chong, C.S., Abdul Razak, M.A., Tan, C.H., Liew, C., Pok, K.Y., Ng, L.C. (2013).Gravitraps for the management of dengue clusters in Singapore. American Journal of Tropical Medicine & Hygiene;88(5): 888-892. [Full Text]
  4. Chan, M., Lin, L., Yap, G., Ng, L.C., Leo, Y.S. (2013).Haemorrhagic fever with renal syndrome, Singapore. Annals Academy of Medicine Singapore; 42(5): 257-258. [PDF]
  5. Yap, G., Li, C., Mutalib, A., Lai, Y.L., Ng, L.C. (2013).High rates of inapparent dengue in older adults in Singapore.American Journal of Tropical Medicine & Hygiene; 88(6): 1065-1069. [Full Text]
  6. Tan, L.K., Lim, S., Low, S.L., Tan, F.H., Ng, L.C., Teo, D. (2013).Evaluation of pathogen reduction systems to inactivate dengue and chikungunya viruses in apheresis platelets suspended in plasma. Advances in Infectious Diseases;3(1): 1-9. [PDF]
  7. Wong, P.S.J., Li, M.Z.I., Chong, C.S., Ng, L.C., Tan, C.H. (2013).Aedes (Stegomyia) albopictus (Skuse): a potential vector of Zika virus in Singapore. PLoS Neglected Tropical Diseases;7(8): e2348.[Full Text]
  8. Koo, C., Nasir A., Hapuarachchi H.C., Lee K.S., Hasan Z., Ng, L.C., Khan, E. (2013). Evolution and heterogeneity of multiple serotypes of dengue virus in Pakistan, 2006-2011. Virology Journal;10: 275. [Full Text]
  9. Cranston, P.S., Ang, Y.C., Heyzer, A., Lim, R.B.H., Wong, W.H., Woodford, J.M., Meier, R. (2013). The nuisance midges (Diptera: Chironomidae) of Singapore's Pandan and Bedok reservoirs. The Raffles Bulletin of Zoology; 61(2): 779-793. [Full Text]
  10. Leo, Y.S., Gan, V., Ng, E.L., Hao, Y., Ng, L.C., Pok, K.Y., Dimatatac, F. (2013). Utility of warning signs in guiding admission and predicting severe disease in adult dengue. BMC Infectious Diseases; 13: 498. [Full Text]
  11. Wilder-Smith, A., Earnest, A., Ma, S., Ng, LC. (2013). Haze and dengue: the unanswered questions. Annals, Academy of Medicine;42(12): 687-688.[PDF]
  12. Ng, L.C., Ho, D. (2013). Challenges of Dengue control. Annals, Academy of Medicine; 42(12): 696-697. [PDF]


  1. Ng, L.C., Vythilingam, I. (2012).Vectors of Flaviviruses and Strategies for Control. Chapter 15 of Molecular Virology and Control of Flaviviruses. Editor: Pei-Yong Shi. Caister Academic Press ISBN: 978-1-904455-92-9.[Link]
  2. Lu, D., Koou, S.Y., Png, A.B., Ng, L.C., Phua, S.G. (2012). A novel mosquito feeding system for routine blood-feeding of Aedes aegypti and Aedes albopictus. Tropical Biomedicine; 29(1): 169-174. [PDF]
  3. Cheong, M.S., Ho, J.S., Tan, C.H., Wong, P.S., Ng, L.C., Toh, C.S. (2012). Development of an electrochemical membrane-based nanobiosensor for ultrasensitive detection of dengue virus. Analytica Chimica Acta; 725: 74-80. [Link]
  4. Li, M.Z., Wong, P.S., Ng, L.C., Tan, C.H. (2012).Oral susceptibility of Singapore Aedes (Stegomyia) aegypti (Linnaeus) to Zika virus. PLoS Neglected Tropical Diseases;6(8): e1792.[Full Text]
  5. Rai, V., Hapuarachchi, H.C., Ng, L.C., Soh, S.H., Leo, Y.S., Toh, C.S. (2012). Ultrasensitive cDNA detection of dengue virus RNA using electrochemical nanoporous membrane-based biosensor. PLoS ONE; 7(8): e42346. [Full Text]
  6. Lee, R.M., Phua, S.G., Tan, W.C., Pang, S.C., Vythilingam, I., Ng, L.C., Rueda, L.M. (2012). Mosquito fauna of Ubin island, Singapore. Journal of the American Mosquito Control Association;28(3): 248-254. [Full Text]
  7. Lee, V.J., Chow, A., Zheng, X., Carrasco, L.R., Cook, A.R., Lye, D.C., Ng, L.C., Leo, Y.S. (2012). Simple clinical and laboratory predictors of chikungunya versus dengue infections in adults. PLoS Neglected Tropical Diseases;6(9): e1786. [Full Text]
  8. Hii, Y.L., Rocklöv, J., Wall, S., Ng, L.C., Tang, C.S., Ng, N. (2012). Optimal lead time for dengue forecast. PLoS Neglected Tropical Diseases;6(10): e1848. [Full Text]
  9. Hii, Y.L., Zhu, H., Ng, N., Ng, L.C., Rocklöv, J. (2012) Forecast of dengue incidence using temperature and rainfall. PLoS Neglected Tropical Diseases;6(11): e1908. [Full Text]
  10. Lee, K.S., Lo, S., Tan, S.S.Y., Chua, R., Tan, L.K., Xu, H., Ng, L.C. (2012).Dengue virus surveillance in Singapore reveals high viral diversity through multiple introductions and in situ evolution. Infection, Genetics and Evolution;12(1): 77-85. [Link]


  1. Tan, C. H., Wong, P.S., Li, M.Z., Vythilingam, I., Ng, L.C. (2011). Evaluation of the dengue NS1 Ag Strip® for detection of dengue virus antigen in Aedes aegypti (Diptera: Culicidae). Vector-Borne and Zoonotic Diseases; 11(6): 789-792. [PDF]
  2. Sumanadasa, S.D.M., Lee, C., Lam-Phua, S.G., Lu, D., Chiang, L.P., Koou, S.Y., Tan, C.H., Pang, S.C., Maideen, N., Ng, L.C., Vythilingam, I. (2011). Misting of Bacillus thuringiensis israelensis (Bti) to control Aedes albopictus in an industrial area – the Singapore experience. Dengue Bulletin; 35: 181-193. [PDF]
  3. Yap, G., Kumar, S.B., Ng, L.C. (2011) Use of saliva for early dengue diagnosis. PLoS Neglected Tropical Diseases;5(5): e1046[PDF]
  4. Ler, T.S., Ng, L.C., Yap, G., Ang, L.W., Tai, J.C., James, L., Goh, K.T. (2011).Epidemiological characteristics of the 2005 and 2007 dengue epidemics in Singapore - similarities and distinctions. Western Pacific Surveillance and Response;2(2): 24-29.[Full Text]
  5. Tan, C.H., Wong, P.S., Li, M.Z., Tan, S., Lee, T.K., Pang, S.C., Phua, S.G., Nasir, M., Png, A.B., Koou, S.Y., Deng, L.,Ng, L.C. (2011). Entomological investigation and control of a chikungunya cluster in Singapore. Vector Borne and Zoonotic Diseases 11(4): 383-390. [PDF]
  6. Lim, Y.H., Kek, R., Lim, P.Y., Yap, J., Goh, V., Ng, L.C. (2011) Environmental surveillance and molecular characterization of Legionella in tropical Singapore. Tropical Biomedicine;28(1): 149-159. [PDF]
  7. Ng, L.C. (2011).Challenges in dengue surveillance and control in the Western Pacific region. Editorial in Western Pacific Surveillance and Response Journal;2(2): 1-3. [Full Text]
  8. Kasai, S., Ng, L.C.Lam-Phua, S.G., Tang, C.S., Itokawa, K., Komagata, O., Kobayashi, M., Tomita, T. (2011). First detection of a putative knockdown resistance gene in major mosquito vector, Aedes albopictusJapanese Journal of Infectious Diseases;64: 217–221. [PDF]
  9. Low, J., Ong, A., Tan, L.K., Chaterji, S., Chow, A., Lim, W.Y., Lee, K.W., Chua, R., Tan, W.S., Cheung, Y.B., Hibberd, M., Vasudevan, S., Ng, L.C., Leo, Y.S., Ooi. E.E. (2011). The early clinical features of dengue in adults: challenges for early clinical diagnosis. PLoS Neglected Tropical Diseases; 5(5): e1191. [PDF]
  10. Jackson, S. T., Chu, J., Chia, P. Y., Morgan, O. S. C. & Ng, L.C. (2011). Dengue Encephalitis. Flavivirus Encephalitis, Daniel Ruzek (Editor). InTech Open Access Publisher ISBN 978-953-307-669-0 [Link]
  11.  Wong, P.S., Tan, C.H., Lee, V., Li, M.Z., Lee, K.S., Lee, P.J., Singh. B., Ng, L.C. (2011). Molecular epidemiological investigation of Plasmodium knowlesi in humans and macaques in Singapore. Vector-Borne and Zoonotic Diseases; 11(2): 131-135. [PDF] 
  12. Rai, V., Nyine, Y.T., Hapuarachchi, H.C., Yap, H.M., Ng, L.C., Li, S.F.Y., Toh, C.S. (2011). Electrochemically amplified molecular beacon biosensor for ultrasensitive DNA sequence-specific detection of Legionella spBiosensors and Bioelectronics; 32(1): 133-140. [Full Text]
  13. Carrasco, L.R., Lee, L.K, Lee, V.J., Ooi, E.E., Shepard, D.S., Thein, T.L., Gan, V., Cook, A.R., Lye, D., Ng, L.C., Leo, Y.S. (2011). Economic impact of dengue illness and the cost effectiveness of future vaccination programs in Singapore. PLoS Neglected Tropical Diseases; 5(12): e1426. [Full Text]
  14. Leo, Y.S., Ng, L.C., Cutter, J. (2011).Dengue research in Singapore marking the inaugural ASEAN Dengue Day.Annals Academy of Medicine Singapore;40(12): 520-523. [PDF] 
  15. Lam, S.K., Burke, D., Capeding, M.R., Chong, C.K., Coudeville, L., Farrar, J., Gubler, D., Hadinegoro, S.R., Hanna, J., Lang, J., Lee, H.L., Leo, Y.S., Luong, C.Q., Mahoney, R., McBride, J., Mendez-Galvan, J., Ng, L.C., Nimmannitya, S., Ooi, E.E., Shepard, D., Smit, J., Teyssou, R., Thomas, L., Torresi, J., Vasconcelos, P., Wirawan, D.N., Yoksan, S. (2011). Preparing for introduction of a dengue vaccine: recommendations from the 1st Dengue v2V Asia-Pacific Meeting. Vaccine; 29(51): 9417-9422. [Full Text]
  16. Zarowieck, M., Walton, C., Torres, E., McAlister, E., Htun, P.T., Sumrandee, C., Sochanta, T., Dinh, T.H., Ng, L.C., Linton, Y.M. (2011). Pleistocene genetic connectivity in a widespread, open-habitat-adapted mosquito in the Indo-Oriental region. Journal of Biogeography; 38(7): 1422-1432. [Full Text]


  1. Lee, K.S., Lai, Y.L., Lo, S., Barkham, T, Aw, P., Ooi, P.L., Tai, J.C., Hibberd, M., Johansson, P., Khoo, S.P., Ng, L.C.(2010). Dengue virus surveillance for early warning, Singapore. Emerging Infectious Diseases; 16(5): 847-849. [PDF]
  2. Ooi, E.E., Wilder-Smith, A., Ng, L.C., Gubler, D.J. (2010). The 2007 dengue outbreak in Singapore. Epidemiology and Infection;138(7): 958-959. [Link]
  3. Jeffery, J., Lee, R., Tan, S.Y., Ng, L.C., Lam-Phua, S.G. (2010). New mosquito species records (Diptera: Culicidae) from Singapore. Tropical Biomedicine;27(1): 138–142. [PDF]
  4. Pursem, V.N., Barkham. T., Ng, L.C., Inoue, M., Manraj, S.S. (2010). Re-emergence of dengue in Mauritius. 2010. Emerging Infectious Diseases;16(4): 716-718. [PDF]
  5. Lee, V., Ow, S., Heah, H., Tan, M.Y., Lam, P., Ng, L.C.Lam-Phua, S.G., Qadir, A., Seet, B. (2010). Elimination of mosquito-borne disease risk through integrated combination strategies in a tropical military training island. American Journal of Tropical Medicine and Hygiene; 82(6): 1024-1029. [PDF]
  6. Yap, G., Pok, K.Y., Lai, Y.L., Hapuarachchi, H.C., Chow, A., Leo, Y.S., Tan, L.K., Ng, L.C. (2010). Evaluation of chikungunya diagnostic assays: differences in sensitivity of serology assays in two independent outbreaks. PLoS Neglected Tropical Diseases;4(7): e753. [PDF]
  7. Ng, L.C., Hapuarachchi, H.C. (2010). Tracing the path of chikungunya virus – evolution and adaptation. Infection, Genetics and Evolution;10(7): 876-885. [Full Text]
  8. Ng, L.C., Lee, K.S., Tan, C.H., Ooi, P.L., Phua, S.G., Lin, R., Pang, S.C., Lai, Y.L., Solhan, S., Chan, P.P., Wong, K.Y., Ho, S.T., Vythilingam, I. (2010). Entomologic and molecular investigation into Plasmodium vivax transmission in Singapore, 2009. Malaria Journal; 9: 305. [PDF]
  9. Vythilingam, I. (2010). Plasmodium knowlesi in humans: a review on the role of its vectors in Malaysia. Tropical Biomedicine; 27(1): 1-12. [PDF]
  10. Hapuarachchi, H.C., Bandara, K.B.A.T., Sumanadasa, S.D.M., Hapugoda, M.D., Lai, Y.L., Lee, K.S., Tan, L.K., Lin, R.T.P., Ng, L.F.P., Bucht, G., Abeyewickreme, W., Ng, L.C. (2010).Re-emergence of chikungunya virus in South-east Asia: virologic evidence from Sri Lanka and Singapore. Journal of General Virology; 91: 1067-1076. [PDF]
  11. Johansson, P., Yap, G., Low, H.T., Siew, C.C., Kek, R., Ng, L.C., Bucht, G. (2010). Molecular characterisation of two hantavirus strains from different rattus species in Singapore. Virology Journal; 2(7): 15. [PDF]
  12. Pok, K.Y., Lai, Y.L., Sng, J., Ng, L.C. (2010). Evaluation of nonstructural 1 antigen assays for the diagnosis and surveillance of dengue in Singapore. Vector-Borne and Zoonotic Diseases; 10(10): 1009-1016. [PDF]