EHI Peer-Reviewed Journal Publications

EHI Peer-Reviewed Journal Publications (Year 2006-2009)


  1. Ng, L.F., Chow, A., Sun, Y.J., Kwek, D.J., Lim, P.L., Dimatatac, F., Ng, L.C., Ooi, E.E., Choo, K.H., Her, Z., Kourilsky, P., Leo, Y. S. (2009). IL-1beta, IL-6, and RANTES as biomarkers of chikungunya severity. PLoS ONE;4(1): e4261. [PDF]
  2. Schreiber, M.J., Holmes, E.C., Ong, S.H., Soh, H.S., Liu, W., Tanner, L., Aw, P.P., Tan, H.C., Ng, L.C., Leo, Y.S., Low, J.G., Ong, A., Ooi, E.E., Vasudevan, S.G., Hibberd, M.L. (2009). Genomic epidemiology of a dengue virus epidemic in urban Singapore. Journal of Virology; 83(9): 4163-4173. [PDF]
  3. Teo, D., Ng, L.C. & Lam, S. (2009). Is dengue a threat to the blood supply? Transfusion Medicine 19(2): 66-77. [PDF]
  4. Leo, Y.S., Chow, A., Tan, L.K., Lye, D.C., Lin, L., Ng, L.C. (2009). Chikungunya outbreak, Singapore. (2008). Emerging Infectious Diseases; 15(5): 836-837. [PDF]
  5. Ng, L.C., Tan, L.K., Tan, C.H., Tan, S.Y.S., Hapuarachchi, H.C., Pok, K.Y., Lai, Y.L., Lam-Phua S.G., Bucht, G., Lin, R, Leo, Y.S., Tan, B.H., Han, H.K., Ooi, P.L., Lyn, J., Khoo, S.P. (2009). Entomologic and virologic investigation of chikungunya, Singapore. Emerging Infectious Diseases; 15(8): 1243-1249. [PDF]
  6. Yew, Y.W., Ng, L.C, Yap, G., Goh, K.T. (2009). Seroepidemiology of dengue virus infection among adults in Singapore. Annals Academy of Medicine Singapore; 38(8): 667-675. [PDF]
  7. Yap, J., Zhen, A.T., Goh, V., Ng, L.C., Vesper, S. (2009). Assessment of mold concentrations in Singapore shopping centers using mold-specific quantitative PCR (MSQPCR) analysis. Indian Journal of Microbiology;49(3): 290-293. [PDF]
  8. Ng, L. C., Lam, S., Teo, D. (2009). Epidemiology of dengue and chikungunya viruses and their potential impact on the blood supply. ISBT Science Series;4(2): 357-367. [PDF]
  9. Pang, S. C., Foo, S.Y., Png, A.B., Lu, D., Phua, S.G., Tang, C.S., Ng, L. C. (2009). Evaluation of a “fogging” canister for indoor elimination of adult Aedes aegyptiDengue Bulletin; 33: 203-208. [PDF]


  1. Ng, O.T.,Ooi, E.E.,Lee, C.C.,Jarrod, L.P., Ng, L.C., Wong, P.S., Tu, T.M., Loh, J.P., Leo, Y.S.(2008). Naturally acquired human Plasmodium knowlesi infection, Singapore. Emerging Infectious Diseases; 14(5): 814-816. [PDF]
  2. Ng, L.C. (2008). Singapore’s first chikungunya outbreak – surveillance and response. Epidemiological News Bulletin; 34(2): 25-28. [Link]
  3. Tanner, L., Schreiber, M., Low, J., Ong, A., Tolfvenstam, T., Lai, Y.L.Ng, L.C., Leo, Y.S., Puong, L.T., Vasudevan, S.G., Simmons, C.P., Hibberd, M.L., Ooi, E.E. (2008). Decision tree algorithms predict the diagnosis and outcome of dengue fever in the early phase of illness in adults. PLoS Neglected Tropical Diseases; 2(3): e196. [PDF]
  4. Tringe, S., Zhang, T., Liu, X., Yu, Y., Lee, W.H., Yap, J., Yao, F., Sim, T.S., Seah, K.I., Haynes, M., Rohwer, F., Chia, L.W., Tan, P., Bristow, J., Rubin, E., Ruan, Y. (2008). The airborne metagenome in an indoor urban environment. PLoS ONE 3(4): e1862. [PDF]
  5. Koh, B., Ng, L.C., Kita, Y., Tang, C.S., Ang, L.W., Wong, K.Y., James, L., Goh, K.T. (2008). The 2005 dengue epidemic in Singapore: epidemiology, prevention and control. Annals of the Academy of Medicine Singapore; 37(7): 538-545. [PDF]
  6. Lim, P.Y., Kek, R., Yap, J., Ng, L.C. (2008). Sequence-based typing (SBT) for investigation of Legionella pneumophilia in environmental water samples. Epidemiological News Bulletin; 34(3): 55-58. 
  7. Toh, Z. A., Goh, V., Yap, J., Ng, L.C. (2008). Surveillance of mould flora in shopping malls in Singapore. Epidemiological News Bulletin; 34(3): 58-62. 
  8. Lee, C.Y., Ng, L.C., Koh, T.H. (2008). Dermatological features of an imported case of chikungunya in an infant. Singapore Medical Journal;49(11): 959-960. [PDF]


  1. Lai, Y.L., Chung, Y.K., Tan, H.C., Yap, H.F., Yap, G., Ooi, E.E., Ng, L.C. (2007). Cost effective real time RT-PCR to screen for dengue followed by rapid single-tube multiplex RT-PCR for serotyping of the virus. Journal of Clinical Microbiology; 45(3): 935-941. [PDF]
  2. Ng, L.C., Lai, Y.L., Cheng, C., Barkham, T.(2007) .Spatial and temporal distribution of dengue serotypes in Singapore. Epidemiological News Bulletin; 33(1): 1-3. 
  3. Kek, R., Yap, J., Ng, L.C. (2007). Sequence-based typing for Legionella pneumophila. Epidemiological News Bulletin;33(1): 8-10. 


  1. Barkham, T.M., Chung, Y.K.Tang, K.F., Ooi, E.E. (2006). The performance of RT-PCR compared with a rapid serological assay for acute dengue fever in a diagnostic laboratory. Transactions of the Royal Society of Tropical Medicine and Hygiene;100(2): 142-148. [Full Text]
  2. Tang, C. S., Pang, F.Y., Ng, L.C., Appoo, S.S. (2006). Surveillance and control of dengue vectors in Singapore. Epidemiological News Bulletin; 32(1): 1-9. 
  3. Kek, R., Yap, J., Goh, V. & Ng, L. C. (2006). Risk of Legionella contamination in household water heating tanks. Epidemiological News Bulletin; 32(1): 18-20. 
  4. Low, J., Ooi, E.E., Tolfvenstam, T., Leo, Y.S., Hibberd, M., Ng, L.C., Lai, Y.L., Yap, G., Li, C., Vasudevan, S.,Ong, A.(2006).Early dengue infection and outcome study (EDEN) - study design and preliminary findings. Annals of the Academy of Medicine Singapore; 35(11): 783-789. [PDF]