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Research
EHI Peer-Reviewed Journal Publications
EHI Peer-Reviewed Journal Publications (Year 2002-2005)
Environmental Health Institute
WHO CC for Reference and Research of Arbovirus and their Associated Vectors
Surveillance and Epidemiology Programme
Vector-Borne Diseases Research Programme
Wolbachia-Aedes Mosquito Suppression Strategy
How Does Wolbachia-Aedes Suppression Technology Work?
Egg Microinjection
Cytoplasmic Incompatibility
Maternal Transmission of Wolbachia
Mating Competitiveness
Why Wolbachia-Aedes suppression technology?
Wolbachia is Safe and Natural
Male Mosquitoes Do Not Bite or Transmit Disease
Project Wolbachia Only Targets Aedes aegypti
Laying the Foundation for Project Wolbachia
Automation and Partnerships to Scale Capacity
Phase 1 Small-Scale Field Study
Phase 2 Field Study
Phase 3 Field Study
Phase 4 Field Study
Phase 5 Field Study
Field Study to Test Targeted Release Strategy
Multi-site Field Study
Wolbachia-Aedes Release Schedule
Wolbachia Video Series
Frequently Asked Questions
Mosquito Traps
Mosquito Traps for Surveillance and Research
Effectiveness of Mosquito Traps
Source Reduction is Key
EHI Peer-Reviewed Journal Publications
EHI Peer-Reviewed Journal Publications (Year 2022-2023)
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Environmental Health Institute
WHO CC for Reference and Research of Arbovirus and their Associated Vectors
Surveillance and Epidemiology Programme
Vector-Borne Diseases Research Programme
Wolbachia-Aedes Mosquito Suppression Strategy
How Does Wolbachia-Aedes Suppression Technology Work?
Egg Microinjection
Cytoplasmic Incompatibility
Maternal Transmission of Wolbachia
Mating Competitiveness
Why Wolbachia-Aedes suppression technology?
Wolbachia is Safe and Natural
Male Mosquitoes Do Not Bite or Transmit Disease
Project Wolbachia Only Targets Aedes aegypti
Laying the Foundation for Project Wolbachia
Automation and Partnerships to Scale Capacity
Phase 1 Small-Scale Field Study
Phase 2 Field Study
Phase 3 Field Study
Phase 4 Field Study
Phase 5 Field Study
Field Study to Test Targeted Release Strategy
Multi-site Field Study
Wolbachia-Aedes Release Schedule
Wolbachia Video Series
Frequently Asked Questions
Mosquito Traps
Mosquito Traps for Surveillance and Research
Effectiveness of Mosquito Traps
Source Reduction is Key
EHI Peer-Reviewed Journal Publications
EHI Peer-Reviewed Journal Publications (Year 2022-2023)
EHI Peer-Reviewed Journal Publications (Year 2002-2005)
2005
Goh, K.T., Ng, D.L.K.,
Yap, J.
, Ma, S., Ooi, E.E. (2005). Surveillance, prevention, and control of
Legionellosis
in a tropical city-state.
American Journal of Infection Control
;
33(5): 286-291.
[Full Text]
Seet, R.C.S.,
Ooi, E.E.
, Wong, H.B., Paton, N.I. (2005). An outbreak of primary dengue infection among migrant chinese workers in Singapore characterised by prominent gastrointestinal symptoms and a high proportion of symptomatic cases.
Journal of Clinical Virology
;
33(4): 336-340.
[Full Text]
Leong, W.F.,
Tan, H.C.
,
Ooi, E.E.
, Koh, D.R., Chow, V.T.K. (2005). Microassay and real-time RT-PCR analyses of differential human gene expression patterns induced by severe actue respiratory syndrome (SARS) coronavirus infection of Vero Cells.
Microbes and Infection
; 7(2): 248-259.
[Full Text]
He, Q., Manopo, I., Lu, L., Leung, B.P., Chng, H.H., Ling, A.E., Chee, L.L., Chan, S.,
Ooi, E.E.
, Sin, Y.L., Ang, B., Kwang, J. (2005). Novel immunofluorescence assay using recombinant nucleocapsid-spike fusion protein as antigen to detect antibodies against severe actue respiratory syndrome coronavirus.
Clinical and Diagnostic Laboratory Immunology
; 12(2): 321-328.
[PDF]
Tan, H.K.,
Ng, L.C.
(2005).
Aedes m
osquito surveillance, control and research in Singapore.
Epidemiological News Bulletin
;
31(3): 62-65. [
PDF
]
Yap, J.
(2004). Best maintenance practices: the way to upkeep good indoor air quality in air-conditioned buildings.
Facility Management Today, Trade Link Media Pte Ltd, Singapore;
21-23.
Liew, C.,
Curtis, C.F. (2004). Horizontal and vertical dispersal of dengue vector mosquitoes,
Aedes aegypti
and
Aedes albopictus
, in Singapore.
Medical and Veterinary Entomology
; 18(4): 351-360.
[Full Text]
Ting, S.H.L.,
Tan, H.C.
, Wong, W.K., Ng, M.L., Chan, S.H.,
Ooi, E.E.
(2004). Seroepidemiology of neutralising of antibodies to Japanese encephalitis in Singapore: continued transmission despite abolishment of pig farming?
Acta Tropica
92(3): 187-191.
[Full Text]
Ng, L.F.P., Hibberd, M.L.,
Ooi, E.E., Tang K.F.,
Neo, S.Y., Tan, J., Murthy, K.R., Vega, V.B., Chia, J.M., Liu, E.T., Ren, E.C. (2004). A human
in vitro
model system for investigating genome-wide host responses to SARS coronavirus infection.
BMC Infectious Diseases
;
4: 34.
[PDF]
Vega, V.B., Ruan, Y., Liu, J., Lee, W.H., Wei, C.L., Se-Thoe, S.Y.,
Tang, K.F.
, Zhang, T., Kolatkar, P.R.,
Ooi, E.E.
, Ling, A.E., Stanton, L.W., Long, P.M., Liu, E.T. (2004). Mutational dynamics of the SARS coronavirus in cell culture and human populations isolated in 2003.
BMC Infectious Diseases
;
4: 32.
[PDF]
Fielding, B.C., Tan, Y.J., Shuo, S., Tan, T.H.P.,
Ooi, E.E.
, Lim, S.G., Hong, W., Goh, P.Y. (2004). Characterisation of a unique group-specific protein (U122) of the severe acute respiratory syndrome coronavirus.
Journal of Virology
;
78(14): 7311-7318.
[PDF]
Tan, E.L.C.,
Ooi, E.E.
, Lin, C.Y.,
Tan, H.C.
, Ling, A.E., Lim, B., Stanton, L.W. (2004). Inhibition of SARS coronavirus infection
in vitro
with clinically approved antiviral drugs.
Emerging Infectious Diseases
; 10(4): 581-586.
[PDF]
Tan, Y.J., Teng, E., Shen, S., Tan, T.H.P., Goh, P.Y., Fielding, B.C.,
Ooi, E.E.
,
Tan, H.C.
, Lim, S.G., Hong, W. (2004). A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis.
Journal of Virology
; 78(13): 6723-6734.
[PDF]
Lu, L., Manopo, I., Leung, B.P., Chng, H.H., Ling, A.E., Chee, L.L.,
Ooi, E.E.
, Chan, S.W., Kwang J. (2004). Immunological characterisation of the spike protein of the severe acute respiratory syndrome coronavirus.
Journal of Clinical Microbiology
;
42(4): 1570-1576.
[PDF]
2004
Yap, J.
(2004). Best maintenance practices: the way to upkeep good indoor air quality in air-conditioned buildings.
Facility Management Today, Trade Link Media Pte Ltd, Singapore;
21-23.
Liew, C.,
Curtis, C.F. (2004). Horizontal and vertical dispersal of dengue vector mosquitoes,
Aedes aegypti
and
Aedes albopictus
, in Singapore.
Medical and Veterinary Entomology
; 18(4): 351-360.
[Full Text]
Ting, S.H.L.,
Tan, H.C.
, Wong, W.K., Ng, M.L., Chan, S.H.,
Ooi, E.E.
(2004). Seroepidemiology of neutralising of antibodies to Japanese encephalitis in Singapore: continued transmission despite abolishment of pig farming?
Acta Tropica
92(3): 187-191.
[Full Text]
Ng, L.F.P., Hibberd, M.L.,
Ooi, E.E., Tang K.F.,
Neo, S.Y., Tan, J., Murthy, K.R., Vega, V.B., Chia, J.M., Liu, E.T., Ren, E.C. (2004). A human
in vitro
model system for investigating genome-wide host responses to SARS coronavirus infection.
BMC Infectious Diseases
;
4: 34.
[PDF]
Vega, V.B., Ruan, Y., Liu, J., Lee, W.H., Wei, C.L., Se-Thoe, S.Y.,
Tang, K.F.
, Zhang, T., Kolatkar, P.R.,
Ooi, E.E.
, Ling, A.E., Stanton, L.W., Long, P.M., Liu, E.T. (2004). Mutational dynamics of the SARS coronavirus in cell culture and human populations isolated in 2003.
BMC Infectious Diseases
;
4: 32.
[PDF]
Fielding, B.C., Tan, Y.J., Shuo, S., Tan, T.H.P.,
Ooi, E.E.
, Lim, S.G., Hong, W., Goh, P.Y. (2004). Characterisation of a unique group-specific protein (U122) of the severe acute respiratory syndrome coronavirus.
Journal of Virology
;
78(14): 7311-7318.
[PDF]
Tan, E.L.C.,
Ooi, E.E.
, Lin, C.Y.,
Tan, H.C.
, Ling, A.E., Lim, B., Stanton, L.W. (2004). Inhibition of SARS coronavirus infection
in vitro
with clinically approved antiviral drugs.
Emerging Infectious Diseases
; 10(4): 581-586.
[PDF]
Tan, Y.J., Teng, E., Shen, S., Tan, T.H.P., Goh, P.Y., Fielding, B.C.,
Ooi, E.E.
,
Tan, H.C.
, Lim, S.G., Hong, W. (2004). A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis.
Journal of Virology
; 78(13): 6723-6734.
[PDF]
Lu, L., Manopo, I., Leung, B.P., Chng, H.H., Ling, A.E., Chee, L.L.,
Ooi, E.E.
, Chan, S.W., Kwang J. (2004). Immunological characterisation of the spike protein of the severe acute respiratory syndrome coronavirus.
Journal of Clinical Microbiology
;
42(4): 1570-1576.
[PDF]
Chow, P.K.H.,
Ooi, E.E.
, Tan, H.K., Ong, K.W.,
Sil, B.K.
, Teo, M., Ng, T., Soo, K.C. (2004). Healthcare worker seroconversion in SARS outbreak.
Emerging Infectious Diseases
; 10(2): 249-250.
[PDF]
He, Q., Chong, K.H., Chng, H.H., Leung, B., Ling, A.E., Wei, T., Chan, S.W.,
Ooi, E.E.,
Kwang, J. (2004). Development of a Western blot assay for detection of antibodies against coronavirus causing severe acute respiratory syndrome.
Clinical and Diagnostic Laboratory Immunology
;
11(2): 417-422.
[PDF]
Tan, Y.J., Goh, P.Y., Fielding, B.C., Shen, S., Chou, C.F., Fu, J. L., Leong, H.N., Leo, Y.S.,
Ooi, E.E.
, Ling, A.E., Lim, S.G., Hong, W. (2004). Profiles of antibody responses against severe acute respiratory syndrome coronavirus recombinant proteins and their potential use as diagnostic markers.
Clinical and Diagnostic Laboratory Immunology
;
11(2): 362-371.
[PDF]
Singh, K.,
Ooi, E.E.
,
Sil, B.K.
, Saw, S., Sethi, S. (2004). Severe acute respiratory syndrome without respiratory symptoms or abnormal chest radiograph findings.
Clinical Infectious Diseases
;
38: 585-586.
[Full Text]
Ng, L.F.P., Wong, M., Koh, S.,
Ooi, E.E.
,
Tang, K.F.,
Leong, H.N., Ling, A.E., Agathe, L.V., Tan, J., Liu, E.T., Ren, E.C.,
Ng, L.C.,
Hibberd, M. L. (2004). Detection of severe acute respiratory syndrome coronavirus in blood of infected patients.
Journal of Clinical Microbiology
; 42(1): 347-350.
[PDF]
Ng, M.L., Lee, J.W.M., Leong, M.L.N., Ling, A.E.,
Tan, H.C.,
Ooi, E.E.
(2004). Topographic changes in SARS coronavirus-infected cells during late stages of infection.
Emerging Infectious Diseases
;
10(11): 1907-1914.
[PDF]
Ho, K.Y., Singh, K.S., Habib, A.G., Ong, B.K., Lim, T.K.,
Ooi, E.E.
,
Sil, B.K.
, Ling, A.E., Bai, X.L., Tambyah, P.A. (2004). Mild illness associated with severe acute respiratory syndrome coronavirus infection: lessons from a prospective seroepidemiologic study of health-care workers in a teaching hospital in Singapore.
The Journal of Infectious Diseases
; 189(4): 642-647.
[Full Text]
2003
Kaur, J.S.
,
Lai, Y.L.,
Giger, A. D.
(2003) Learning and memory in the mosquito
Aedes aegypti
shown by conditioning against oviposition deterrence.
Medical and Veterinary Entomology
;
17(4): 457-460.
[Full Text]
Ng, M.L., Tan, S.H.,
See, E.E.
,
Ooi, E.E.,
Ling, A.E. (2003). Proliferative growth of SARS coronavirus in Vero E6 cells.
Journal of General Virology
;
84(12): 3291-3303.
[PDF]
Ng, M.L., Tan, S.H.,
See, E.E.
,
Ooi, E.E.,
Ling, A.E. (2003). Early events of SARS coronavirus infection in Vero cells.
Journal of Medical Virology
;
71(3): 323-331.
[Full Text]
Ooi, E.E.,
Goh, K.T., Wang, D.N.C. (2003). Effect of increasing age on the trend of dengue and dengue haemorrhagic fever in Singapore.
International Journal of Infectious Diseases
; 7: 231-232.
[PDF]
Liu, Y., Lee, M.A.,
Ooi, E.E.
, Mavis, Y., Tan, A.L., Quek, H.H. (2003). Molecular Typing of
Salmonella enterica
serovar Typhi isolates from various countries in Asia by a multiplex PCR assay on variable-number tandem repeats.
Journal of Clinical Microbiology
;
41(9): 4388-4394.
[PDF]
2002
Chung, Y.K.,
Pang, F.Y.
(2002). Dengue virus infection rate in field populations of female
Aedes aegypti
and
Aedes albopictus
in Singapore.
Tropical Medicine and International Health
;
7(4): 322-330.
[Full Text]